Exploring Pharmacokinetic interactions between SHR8554, a µ-opioid receptor biased agonist, and Itraconazole in healthy Chinese subjects.

Sci Rep · 2025 · PMC12218957 · PMID 40593123

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an increasing trendno p-value reported

Nevertheless, following the inhibition of CYP3A4 enzyme activity by itraconazole, there was an increasing trend in the incidence of TEAEs (93.8% vs. 75%) compared to when SHR8554 was administered alone.

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