The role of venoactive compounds in the treatment of chronic venous disease.

33 , 42 Red vine leaf extract significantly reduced CVD-related symptoms vs placebo; more specifically, the first trial randomized 260 patients and showed a highly significant decrease in the intensity of leg heaviness, tightness, paresthesiae, and pain. 42 It is important to note that only pain reduction was significant at 6 weeks and that the other symptoms were significantly reduced at the 12-week follow-up.

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