TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy.

29 We found that the P-RELA to RELA ratio showed an increasing trend with LPS exposure, regardless of whether it was in the colon of the offspring of the Tlr4 fl/fl or Tlr4 ΔIEC mice, and there was no significant interaction between LPS exposure and Tlr4 knockout ( Fig. 3 B, C).

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