Barely Significant
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Global and regional burden of four drug use disorders in the elderly, 1990 to 2021: an analysis of the global burden of disease study.

BMC Geriatr · 2025 · PMC12220652 · PMID 40604442

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a decreasing trendno p-value reported
Conversely, if both the APC or AAPC and their 95% CI are less than zero, this indicates a decreasing trend in rates.

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an increasing trendno p-value reported
In opioid use disorders, both men and women’s ASIR showed a decreasing trend, while ASDR showed an increasing trend in women and a decreasing trend in men (Fig.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.