Investigation of <i>LBX1, TIMP2, GPR126</i> and <i>CHD7</i> Gene Polymorphisms in Adolescent Idiopathic Scoliosis Patients.

26 , 28 - 31 A subsequent meta-analysis, which included 5,159 patients with AIS and 17,840 controls, reported a highly significant association with this SNP, with a P = 1.22 × 10 -43 for both men and women, and an even stronger P = 2.94 × 10 -48 for women only. 32 The present study established a significant association between the LBX1 polymorphism rs11190870 and AIS susceptibility ( P < .001), consistent with prior research conducted across diverse populations, particularly in East Asian cohorts.

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