Reinforcing this result, increasing trends were also observed in the expression of EMT and TGF-β signalling gene sets, previously associated with the basal-like subtype, and a decreasing trend was observed in the expression of a pancreatic progenitor gene set, which has previously been associated with the classical subtype (Fig.
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Analysis of an engineered organoid model of pancreatic cancer identifies hypoxia as a contributing factor in determining transcriptional subtypes.
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