Biological Mechanisms for Allen's Rule: DNA Methylation as Mediator of the Association Between In Utero Exposure to Environmental Heat and Tibial Growth in Childhood.

As shown in Table 7 (with full annotations in the Supporting Information ), we found 37 mediators in total, of which 14 were significant at pFDR < 0.05, and 23 were marginally significant at pFDR < 0.10.

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At pFDR < 0.10 (marginal significance), we found 1 mediator (cg05213070) of the association between the > 37°C LST cutoff and children's tibial‐length‐forage z score, hypermethylated in the gene body of DEFB132 (Defensin Beta 132).

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