How to choose optimal adjuvant therapies for high-risk hormone receptor-positive, HER2-negative breast cancer after chemotherapy?

Acta Oncol · 2025 · PMC12228045 · PMID 40557948

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borderline significantno p-value reported

Letrozole significantly decreased distant recurrences (hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.43–0.84), and node-positive patients also demonstrated a borderline significant overall survival benefit (HR 0.61, 95% CI 0.38–0.98) [ 41 ].

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