Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer's disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance.

We found that WT-iAstro, transfected with 10 nm-BFP, showed a significant reduction of cells with punctate-vesicular GFP-LC3 pattern (44.85%, p < 0.0001 compared with WT-iAstro-ER-BFP), while Tg-iAstro, transfected with 20 nm-BFP showed partial but highly significant recovery of cells with punctate-vesicular GFP-LC3 localization (51.69%, p < 0.0001 compared with Tg-iAstro-ER-BFP) (Fig. 7 ).

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