The Evolving Global Burden of Young-Onset Parkinson's Disease (1990-2021): Regional, Gender, and Age Disparities in the Context of Rising Incidence and Declining Mortality.

Notably, from 1990 to 2021, mortality in two SDI regions showed an increasing trend (high SDI and low‐middle SDI regions), with the largest upward trend observed in high SDI region [EAPC = 0.20 (95% CI: 0.14, 0.27)], whereas mortality in three SDI regions showed a decreasing trend, with the most significant decrease observed in the high‐middle SDI region [EAPC = −1.07 (95% CI: −1.18, −0.96)].

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