Our analysis of airway mechanics in mice revealed that reducing club cell Bdnf through conditional knockout had no major impacts on IL-13-mediated AHR, although a statistical trend for loss Bdnf to mitigate AHR was noted in female mice.
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Club cell-derived brain-derived neurotrophic factor regulates murine airway mechanics and mucin production in response to IL-13 in a sex-dependent manner.
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