Unveiling therapeutic targets and preventive components for kidney insufficiency and blood stasis-type BPH: bridging metabolomics, network pharmacology and reverse screening.

Front Pharmacol · 2025 · PMC12230579 · PMID 40626307

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In addition, the tissue enzyme level of SRD5α2 exhibited an increasing trend ( P < 0.001), and the nuclear factor NF-κB p65 and the transforming growth factor TGF-β also showed a significant upward trend ( P < 0.001). 3.2 Metabolomics study 3.2.1 Metabolic profile analysis Metabolomic studies were conducted using the UHPLC-Q-Orbitrap HRMS technique.

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