highly significantp value < 0.001
No major changes in vital signs and weight were noted across the three arms throughout the 6-month treatment period. Secondary outcomes The increases in the percentage of CD4 + FoxP3 + CD25 high Treg from the baseline levels were highly significant ( p value < 0.001) across all the six timepoints (D8, D36, D64, D92, D120, D148) throughout the treatment phase in both the IL-2 q2wk and IL-2 q4wk arms, compared to the placebo arm.