Machine-learning based strategy identifies a robust protein biomarker panel for Alzheimer's disease in cerebrospinal fluid.

Alzheimers Res Ther · 2025 · PMC12232211 · PMID 40616179

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highly significantP = 6.6e-36actually significant

Our analysis revealed a highly significant correlation between the 12-protein panel and the classical AD biomarkers (297_CSF: positive correlation: Aβ 42 , R = 0.31, P = 7.5e-0.8; Aβ 42/tau , R = 0.64, P = 6.6e-36; negative correlation: p-tau, R =-0.62, P = 7.5e-33; t-tau, R =-0.76, P = 2.4e-57; Fig. 3 A).

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