ASIC1a Promotes nucleus pulposus derived stem cells apoptosis through modulation of SIRT3-dependent mitochondrial redox homeostasis in intervertebral disc degeneration.

Knockdown of ASIC1a inhibited the mitochondrial apoptotic pathway in human NPSCs The expression of ASIC1a exhibits an increasing trend in acid-treated human NPSCs.

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Second, JC-1 staining results indicated that acid treatment increased the loss of MMP in human NPSCs, showing a decreasing trend in the red to green fluorescence ratio ( Figure 2 H, I).

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