Multi-omics reveals EGCG's anti-calcification effects associated with gut microbiota and metabolite remodeling.

3 Results 3.1 Effects of epigallocatechin-3-gallate on vitamin D3-induced vascular calcification Before the fourth week of vitamin D3 injection, the body weights of all groups were on an increasing trend, but after the fifth week of vitamin D3 injection, there was a decrease in both the VD group and the VD+EGCG group, and the body weights of the VD group and the VD+EGCG group became lighter with the longer duration of vitamin D3 injection ( Figure 1B ).

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