Mechanisms of Lushi Runzao decoction in Treating Sjögren's syndrome by remodeling gut flora to regulate bile acid and short-chain fatty acid metabolism.

The results ( Figures 2E,F ) showed that compared to the Control group, the Model group had elevated levels of anti-SSA and anti-M3R antibodies (anti-SSA: P < 0.05, anti-M3R: P < 0.01); compared to the Model group, the HCQ group showed a decreasing trend in anti-SSA and anti-M3R antibodies levels (anti-SSA: P > 0.05, anti-M3R: P < 0.05), while the LSRZT group had reduced levels of anti-SSA and anti-M3R antibodies (anti-SSA: P < 0.05, anti-M3R: P < 0.01), which were lower than the HCQ group. 3.3.4 LSRZT relieved submandibular gland tissue damage The results of HE staining ( Figures 2G–J ) showed that there was no lymphocyte infiltration in the submandibular glands in the Control group, and the cells were arranged in a regular and orderly manner.

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