Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis.

The human cDNAs were roughly equivalent to one another, although there was a nonsignificant trend of increased activity for ph F8 -ΔF. pz f8 injected into wild-type larvae similarly exhibited thrombus formation consistent with the f8 +/+ ; at3 –/– mutant phenotype ( Figure 5 D).

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