Barely Significant
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Adherence to life's essential 8 is associated with delayed white matter aging.

EBioMedicine · 2025 · PMC12242590 · PMID 40280025

Europe PMCDOI
2
hedged sentences
0.0290
closest p · 0.6× alpha
0.0290
boldest claim

The sentences

marginal significancep = 0.029actually significant
No overall interaction between LE8 and APOE4 status was observed; however, a few single LE8 component x APOE4 interactions showed marginal significance among women or men ( p = 0.029 for BMI x APOE4 in women and p = 0.036 for Diet x APOE4 in men; Supplementary Table S11 ).

also in 5,069 other papers

borderline significanceno p-value reported
Potential interaction between APOE4 and LE8 on brain ageing was observed for some age and sex groups but with only borderline significance, further investigation in larger and more targeted studies is needed to validate the finding.

also in 7,017 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.