In a study in adults with OI, the muscle–bone relationships (although highly significant) differed from controls 6 similar to observations in a homozygous oim mouse model. 15 Homozygous oim mice model severe human type III OI, which is characterized by bone fragility, reduced BMD, and smaller body size. 23 Despite lower peak force, oim muscles were still capable of creating osteogenic levels of strain albeit at much higher percentages of maximum force.
1
—
—