Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells.

Nat Commun · 2025 · PMC12246114 · PMID 40640147

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highly significantno p-value reported

We found a highly significant, positive enrichment for innateness genes in 7 out of 8 antigen-specificities in older adults (Fig. 6E ), indicating that a gain in innateness is a common signature of memory T cell aging.

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