Irisin Prevents the Effects of Simulated Microgravity on Bone and Muscle Differentiation Markers.

Gene analysis on MLO‐Y4 showed that under simulated microgravity conditions there were significant decreases in gene levels of podoplanin ( Pdpn ), expressed in the early stages of the differentiation process from osteoblasts into osteocytes, and Dentin Matrix Protein 1 ( Dmp1 ), involved in matrix mineralization, as well as a decreasing trend in the levels of Matrix Extracellular Phosphoglycoprotein ( Mepe ), also involved in phosphate homeostasis.

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