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Tissue extracellular vesicles suppress neonatal cardiac regeneration: a Pak2-Erk1/2-mediated macrophage paracrine signaling.

Acta Biochim Biophys Sin (Shanghai) · 2025 · PMC12247129 · PMID 39949198

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a pronounced trendno p-value reported
Notably, among these cell populations, macrophages exhibited a pronounced trend consistent with the upregulation of P8-EV mRNA, suggesting that EVs secreted by various cardiac cell types are predominantly internalized by macrophages upon release.

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