Barely Significant
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Evaluation of Blood-Based Diagnostic Biomarkers for Canine Cognitive Dysfunction Syndrome.

Animals (Basel) · 2025 · PMC12249050 · PMID 40646873

2
hedged sentences
0.0580
closest p · 1.2× alpha
0.0580
boldest claim

The sentences

marginally significantp = 0.058so close (0.05 < p ≤ 0.1)
Dogs with mild and severe impairment had significantly higher NfL levels than the AC group, and a marginally significant increase was also observed between the YC and severe groups ( p = 0.058), suggesting a potential early elevation of serum NfL in the transition from normal aging to advanced cognitive decline ( Figure 5 C).

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a decreasing trendno p-value reported
In contrast, GFAP did not show statistically significant differences across CDS stages, despite a decreasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.