Investigating Protective Effect of Suspension of Paeoniflorin in Combination with Curcumin Against Acute Liver Injury Based on Inhibition of TLR4/NF-κB/NLRP3 Inflammatory Pathway.

In this experiment, the body weight of all the mice showed an increasing trend; the CON group showed a steady weight increase, the PF group showed the slowest weight increase, and the CUR group showed the fastest weight increase, which was in line with the above findings.

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In this study, we found that the T-SOD, GSH-Px, and CAT activities in the livers of the LD group showed a decreasing trend and the MDA content was highly significantly increased compared with that in the CON group, which is consistent with the results of the existing reports, indicating that LPS-activated inflammation induced ROS generation, which led to increased oxidative stress in the liver [ 30 , 31 ].

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