Chimeric Antigen Receptor (CAR)-NK92 cells effective against glioblastoma, breast- and pancreatic cancer in vitro and in a murine xenograft model of ovarian cancer.

In contrast to the 2D model the cytotoxicity of CD44v6-CAR-NK92 cells was highly significant against all lines tested in the 3D model, U-138-MG MCTS (Fig. 2 A), GAMG MCTS (Fig. 2 B) and U-251-MG MCTS (Fig. 2 C) at all E: T ratios compared to Empty-CAR-NK92 cells, where the cytotoxicity reached at the highest ratio [1:1] of approximately 80% for all cell lines.

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