Barely Significant
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G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells.

Genome Biol · 2025 · PMC12255116 · PMID 40646632

2
hedged sentences
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

borderline significancep = 0.06so close (0.05 < p ≤ 0.1)
However, the effects of G4 sequences at promoters only had borderline significance ( p = 0.06, Fig. 4 A), similarly to that observed for PEO1 and PEO4 cells.

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highly significantno p-value reported
In contrast, we observed a highly significant association between G4 accumulation at introns and intergenic regions and increased gene expression.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.