A scatter plot comparing the fold-change of differentially regulated genes (DEGs) in “MLN vs control” compared to “Both vs control” revealed a highly significant correlation (Fig. 8E ), suggesting that ARF depletion does not substantially alter the effects of MLN4924 3 days after drug treatment.
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SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation.
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