A further highly significant feature observed in TS-C4 is the location of the p -bromo substituent of the arylcyclohexane outside of the bowl, which explains why a variety of p -substituents, even large groups such as a steroid, can be accommodated.
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Impact of Induced Fitting and Secondary Noncovalent Interactions on Site-Selective and Enantioselective C-H Functionalization of Arylcyclohexanes.
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