Molecular subtype of recurrent implantation failure reveals distinct endometrial etiology of female infertility.

J Transl Med · 2025 · PMC12257665 · PMID 40660214

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantp = 1.69 × 10 − 6actually significant

In the RIF-M subtype, the dysregulated genes were primarily linked associated with LH + days and smoking status: TM7SF2 exhibited the strongest negative correlation with LH + days ( p = 2.65 × 10 − 5 , R = -0.35), and NFIA demonstrated a highly significant negative correlation with smoking status ( p = 1.69 × 10 − 6 , R = -0.18) (Fig. 4 D).

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borderline significantp = 0.07so close (0.05 < p ≤ 0.1)

The study also revealed that DOK5 exhibited a borderline significant correlation with endometrial thickness ( p = 0.07, R = 0.27), which potentially contributes to endometrial abnormalities by inhibiting cell proliferation and differentiation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.