<i>S100a4</i><sup>+</sup> alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism.

Elife · 2025 · PMC12259021 · PMID 40658605

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Moreover, analysis of The Cancer Genome Atlas (TCGA) database indicated that the initiation-associated marker LDHA was highly expressed in LUAD and showed an increasing trend in the early stages of the disease, and its high expression was correlated with poor prognosis of LUAD patients ( Figure 2D–F ).

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&lt;i&gt;S100a4&lt;/i&gt;&lt;sup&gt;+&lt;/sup&gt; alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism.

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<i>S100a4</i><sup>+</sup> alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism.