Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses.

We first compared the effects of the cytosolic PLA2 inhibitor AACOCF3 on macrophage cytokine production in response to TBWCL and identified a highly significant effect on Mtb-induced TNF secretion at the 10 μM dose ( Figure 2C ; P < 0.0001).

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