Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques.

J Clin Invest · 2025 · PMC12259264 · PMID 40662355

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0640

boldest claim

The sentences

a positive trendP = 0.05actually significant

Conversely, in aged RMs, Ki-67 + CD8 + T cells positively correlated with EAA in the spleen ( P = 0.012) and displayed a positive trend with EAA in the cerebellum ( P = 0.05).

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trending toward significanceP = 0.064so close (0.05 < p ≤ 0.1)

IL-8 did not follow this pattern, but yielded higher levels in the old RMs in acute and early chronic infection, trending toward significance ( P = 0.064 and P = 0.065) ( Figure 3G and Supplemental Figure 4G ).

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