Antihypertensive medications and cancer risk: Evidence from 0.27 million patients with newly diagnosed hypertension.

Front Pharmacol · 2025 · PMC12259635 · PMID 40667503

Europe PMC DOI

hedged sentences

0.0330

closest p · 0.7× alpha

0.0580

boldest claim

The sentences

marginally significantp = 0.033actually significant

In sensitivity analysis 10, we observed only a marginally significant association between ACE inhibitors and gastric cancer (HR: 1.27, 95% CI: 1.02–1.59, p = 0.033), which remained consistent (HR: 1.27, 95% CI: 1.02–1.59, p = 0.033) after adjusting for baseline Helicobacter pylori infection status among participants.

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marginal significancep = 0.058so close (0.05 < p ≤ 0.1)

Compared with the other antihypertensive agents after propensity score matching, CCB was associated with increased cancer risk (HR = 1.05; 95% CI: 1.01, 1.09; p = 0.017), whereas marginal significance was shown in association between ARB and a lower cancer risk (HR = 0.96; 95% CI: 0.93, 1.00; p = 0.058). β-Blocker, TD, and ACEI showed no significant association with cancer risk ( p > 0.05).

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