The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.” CDCA induces gastric mucosa apoptosis and intestinal metaplasia in mice CDCA caused a significant decrease in Bcl-2 levels at 50 and 100 mg/kg groups compared to the control group, while Bax and Cdx2 mRNA levels showed an increasing trend without statistical significance ( Fig 2A – C ).
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Chenodeoxycholic acid triggers gastric mucosal injury by inducing apoptosis and FXR activation.
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