Synergistic activity of simvastatin and irinotecan chemotherapy against glioblastoma converges on TGF-β signaling.

J Neurooncol · 2025 · PMC12263772 · PMID 40434539

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In addition to TGF-β, we also noted significant modulation of ERK/MAPK1/2 phosphoprotein levels, which was correlated with significant enrichment of the KRAS signaling pathway in transcriptomic analysis; this may be significant given the role of RAS signaling in oncology and GBM [ 59 ].

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