Genome-level selection in tumors as a universal marker of resistance to therapy.

Nat Commun · 2025 · PMC12263839 · PMID 40664650

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a decreasing trendno p-value reported

The dN/dS values before and after treatment significantly correlated, with a shift towards neutrality at relapse, whereby in cases with dN/dS < 1 before treatment, the dN/dS values tended to increase at relapse, and in cases with dN/dS > 1, there was a decreasing trend of dN/dS at relapse (Fig. 2a ).

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