Association of circulating immuno-oncology biomarkers with breast cancer risk: insights from two prospective cohorts.

NPJ Precis Oncol · 2025 · PMC12263894 · PMID 40665092

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marginally significantno p-value reported

Notably, the mediation analysis in UKB-PPP showed that HGF significantly mediated the effects of HLI (27.17%) and BMI (19.79%), as well as a marginally significant mediation effect concerning physical activity measured in MET (20.38%) on breast cancer risk.

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borderline significantno p-value reported

The only prospective study reported borderline significant association of Caspase-8 (CASP8) with short-term breast cancer risk 12 .

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