Kushenol I combats ulcerative colitis <i>via</i> intestinal barrier preservation and gut microbiota optimization.

Additionally, mice in the model group demonstrated a decreasing trend in SOD activity and a significant reduction in GSH-PX activity ( P < 0.05), whereas KSCI intervention resulted in a significant increase in GSH-PX and SOD activities in mice with DSS-induced UC ( P < 0.001).

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KSCI intervention relieved oxidative stress in the colons of mice with UC MPO and MDA levels in the colons of mice exhibited an increasing trend after DSS exposure, indicating increased oxidative stress (Figure 7 ).

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