Furthermore, we identified highly significant correlations between tumor cell–specific HAF and CD3 + or CD68 + cells, suggesting that the expression of HAF in CD3 + /CD68 + cells may be driven by factors that also induce HAF in tumor cells (Supplemental Figures S6F, G, http://links.lww.com/HEP/I650 ).
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HAF prevents hepatocyte apoptosis and progression to MASH and HCC through transcriptional regulation of the NF-κB pathway.
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