The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma.

[ 8 ] and Pfister [ 7 ] cohorts highlighted highly significant associations between EIF4EBP1 and MYC mRNA levels in the MYC -amplified MB subgroups, namely Group 3 subgroup gamma (corresponding mainly to subtype II [ 42 ]) ([r] 0.704, p value < 0.0001; Supplementary Fig. 2E ) and subtypes II, III and V combined ([r] 0.604, p value < 0.0001; Supplementary Fig. 2F ), confirming co-expression of EIF4EBP1 and MYC in MYC-driven MB tissues.

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