highly significantp < 0.001
For example, in Figure S9 D and its corresponding bar graphs, the wildtype α 1A AR exhibited a significant decrease starting at 50 nM (mean difference: −0.84; fold change: 0.87, p < 0.001), whereas F86M showed a highly significant decrease only at 5 μM (mean difference: −2.12; fold change: 0.66, p < 0.001).