C/EBPβ-VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD.

Furthermore, in a microarray analysis dataset ( GSE106737 ) comparing the liver transcriptome of patients with MASLD before and after treatment, hepatic VCAM1 expression was significantly decreased in patients with MASLD responding effectively to lifestyle intervention (LI) or exhibited a decreasing trend in patients with MASLD receiving Roux-en-Y gastric bypass (RYGB).

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We found that Vcam1 expression in KCs was significantly increased by the methionine-choline deficient diet (MCD) or AMLN diet, or exhibited an increasing trend in mice fed a Western diet ( Fig. 6 C).

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