New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma.

Of note, two recent Mendelian randomisation (MR) studies have attempted to demonstrate a genetic causal association between T2D and POAG based on genome-wide association study (GWAS) data, but there was significant variability in the results: the causal association between T2D and POAG was marginally significant in populations of European ancestry but not in other populations. 9 18 Therefore, it is important to further search for specific genomic variants or loci that explain genome-wide genetic correlations and to delve deeper into the common genetic aetiology and mechanisms between these two diseases. 19

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