A time-series analysis of the use of opioid medications in a network of Brazilian hospitals, 2009-2020.

Lancet Reg Health Am · 2025 · PMC12273242 · PMID 40688763

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an increasing trendno p-value reported

Although evidence for general and prescribed opioid use in Brazil indicates an increasing trend, as made evident by independent population-based surveys, as well as the available official data on prescription, dispensation, and procurement of opioids, there are no studies that describe the profile of use and Defined Daily Dose (DDD) patterns or other similar indicators of opioids for hospitalized patients over time.

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a decreasing trendno p-value reported

Significant values represent an increasing trend if the value is positive and a decreasing trend if it is negative.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.