Identification of biomarkers for Laryngeal squamous cell carcinoma through Mendelian randomization and integrated bioinformatics analysis.

Discov Oncol · 2025 · PMC12274188 · PMID 40679719

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.3300

boldest claim

The sentences

highly significantp = 1.3e−08actually significant

5 e), TMB values also increased with the progression of the stage, with highly significant differences in TMB between T2 and T4 ( p = 1.3e−08) and between T1 and T4 ( p = 0.0001).

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close to significancep = 0.33not close (p > 0.1)

The difference in TMB between G2 and G4 was close to significance ( p = 0.33), while the difference between G2 and G3 was not significant ( p = 0.84).

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an increasing trendno p-value reported

5 d), TMB values showed an increasing trend with the progression of the stage, with statistically significant differences in TMB between Stage I and Stage (IVp = 0.00059) and between Stage II and Stage IV ( p = 0.0066).

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