Sustained and specific multiplexed immune checkpoint modulation in CAR T cells induced by targeted epigenome editing.

Mol Ther Nucleic Acids · 2025 · PMC12275148 · PMID 40686859

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highly significantno p-value reported

In both cases, the target genes were among the highly significant downregulated genes with 3.4-fold decrease in PDCD1 expression and 1.8-fold decrease in LAG3 expression in the respective samples.

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