Electroacupuncture and Parecoxib Reduce Inflammatory Injury in a Primary Dysmenorrhea Rat Model: Investigating the Role of the COX-2/NF-κB/NLRP3 Pathway.

J Pain Res · 2025 · PMC12275913 · PMID 40687333

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The uterine tissues in the treatment groups showed reduced NF-κBp65 nuclear translocation and a decreasing trend in COX-2, NF-κBp65, phospho-NF-κBp65, NLRP3, ASC, pro-caspase-1, caspase-1, IL-1β, and IL-18 protein expression compared with that of the controls.

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