Transcriptome remodelling and changes in growth and cardiometabolic phenotype result following Grb10a knockdown in the early life of the zebrafish.

The observation of 6 cardio-metabolic disease genes out of 29 represents a highly significant enrichment (Fisher’s Exact Test p -value = 0.0006 [2-tailed], odds ratio = 29).

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P -values < 0.05 (where applicable corrected for multiple testing) were taken to indicate significance, and p-values between 0.1 and 0.05 indicating marginal significance.

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