Elevation of NTN4 Expression and Its Possible Regulation by Tumor Necrosis Factor-Alpha (TNF-α) in a Rat Model of Rotator Cuff Tear.

Results Gene expression of NTN4, inflammatory cytokines, MMPs, and CXCL1 following rotator cuff injury Compared with intact tendons (day 0), Ntn4 expression showed no significant change at day 7 (P = 0.257) but rose markedly thereafter, with highly significant increases at days 14 and 28 (both P < 0.001) and remained elevated at day 56 (P = 0.007) (Figure 1A ).

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